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- Seven Cities of Gold, The
- Shalom
- Shenmue
- Shenmue II
- Sherlock Holmes: The Awakened (2023)
- Silent Hill
- Silent Hill 2
- Silent Hill 3
- Silent Hill 4: The Room
- Simon the Sorcerer 3D
- Simulacra
- SOS
- Soul of the Samurai
- Star Control II
- Star Control 3
- Stories Untold
- Sunless Sea
- Sunless Skies
- Syberia: The World Before
