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- Save Room
- Serious Sam Spin-Offs After Serious Sam 3
- Serious Sam 4
- Shadow Warrior (2013)
- Shadow Warrior 2
- Shadow Warrior 3
- Shantae and the Seven Sirens
- Sherlock Holmes: Crimes & Punishments
- Sherlock Holmes: The Awakened (2023)
- Sherlock Holmes: The Devil’s Daughter
- She Sees Red
- Sinking City, The
- Sleeping Dogs
- Stardew Valley
- Streets of Rage 4
- SuperEpic
- Super Hydorah
- Super Time Force
